Coronary and visceral vasoactivity associated with eating and digestion in the conscious dog.

VATNER, STEPHEN F., DEAN FRANKLIN, AND ROBERT L. VAN CTTTERS. Goronmy and uixmzl uasoactioity associated with eating and digestion in the conscious dog. Am. J. Physiol. 219(5):1380-1385. 1970.-The modifications in regional blood flow and vasoactivity in response to eating and digestion were studied in conscious dogs after full recovery from instrumentation with ultrasonic or electromagnetic flow probes on the ascending aorta, left circumflex coronary, mesenteric, renal and iliac arteries, and miniature pressure gauges in the aorta. The presentation and ingestion of food by the resting conscious dog caused cardiac output (62yQ), arterial pressure (33%), heart rate ( 79y0), mesenteric resistance (4@&), and renal resistance (24y0) to increase transiently while iliac (337~) and coronary (62y0) resistance decreased transiently. Mesenteric flow began to increase within 5 min after eating and reached a peak of 132y0 b a ove control within 30-90 min (avg 55 min) and gradually returned to preprandial control levels over the next 2-6 hr. Iliac flow was decreased slightly (10%) 30-60 min postprandially as long as the dog did not walk about. Within lo-30 min renal and coronary flow and resistance returned to preprandial control levels and remained there during peak mesenteric vasodilatation.